Contact Information:
David A. Bluemke, MD, PhD, MsB, FAHA
Russell H. Morgan Department of Radiology and Radiological
Science
Professor of Radiology and
Medicine
Department of Radiology
MRI Building Rm 143
600 N. Wolfe Street
Johns Hopkins University School of Medicine
Baltimore MD, 21287-0845
tel: (410) 955-4062, fax: (410) 955-9799
dbluemke@jhmi.edu
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Research Interests:
- Novel cardiovascular MRI and CT methods in the
evaluation of myocardial ischemia, heart failure and vascular imaging
- Evaluation of the regional function and pathology of
the right heart
- Use of MRI in assessment of markers of subclinical
cardiovascular disease.
- Novel methodology in the assessment of oncologic
disease
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Selected Publications:
Tandri H, Daya SK, Nasir K,
Bomma C, Lima JA, Calkins H, Bluemke
DA. Normal reference values for the
adult right ventricle by magnetic resonance imaging. Am J Cardiol. 2006 Dec 15;98(12):1660-4.
Epub 2006 Oct 27.
PMID: 17145230
Gottlieb I, Macedo R, Bluemke DA, Lima JA. Magnetic resonance imaging in the evaluation of
non-ischemic cardiomyopathies: current
applications and future perspectives. Heart Fail Rev. 2006 Dec;11(4):313-23.
PMID: 17131077
Vogel-Claussen J, Pannu H, Spevak PJ, Fishman
EK, Bluemke DA. Cardiac valve assessment with MR imaging and 64-section
multi-detector row CT. Radiographics. 2006
Nov-Dec;26(6):1769-84. PMID: 17102049
Kamel IR, Reyes DK, Liapi E, Bluemke DA, Geschwind JF. Functional MR imaging assessment of tumor response after
90Y microsphere treatment in patients with unresectable
hepatocellular carcinoma. J Vasc
Interv Radiol. 2007 Jan;18(1 Pt 1):49-56.
PMID: 17296704
Nasir K, Tsai M, Rosen BD, Fernandes V, Bluemke DA, Folsom AR, Lima
JA. Elevated homocysteine is
associated with reduced regional left ventricular function: the
Multi-Ethnic Study of Atherosclerosis. Circulation.
2007 Jan 16;115(2):180-7. Epub 2007 Jan 2.
PMID: 17200444
Silber HA, Lima JA, Bluemke DA, Astor BC, Gupta SN, Foo TK, Ouyang P. Arterial reactivity in lower extremities is
progressively reduced as cardiovascular risk factors increase: comparison
with upper extremities using magnetic resonance imaging. J Am Coll Cardiol. 2007 Mar 6;49(9):939-45. Epub 2007 Feb 16. PMID: 17336716
Rosen BD, Cushman M, Nasir K, Bluemke DA, Edvardsen T, Fernandes
V, Lai S, Tracy RP, Lima JA. Relationship between C-reactive
protein levels and regional left ventricular function in asymptomatic
individuals: the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol. 2007 Feb 6;49(5):594-600. Epub 2007 Jan 22. PMID: 17276184
Lehman CD, Gatsonis C, Kuhl CK, Hendrick RE,
Pisano ED, Hanna L, Peacock S, Smazal SF, Maki DD, Julian TB, DePeri ER, Bluemke DA, Schnall MD; ACRIN Trial
6667 Investigators Group. MRI evaluation of the contralateral breast in women with recently diagnosed
breast cancer. N Engl J Med. 2007 Mar 29;356(13):1295-303
Kawamoto
S, Permpongkosol S, Bluemke DA, Fishman EK, Solomon SB. Sequential changes after radiofrequency
ablation and cryoablation of renal neoplasms: role of CT and MR imaging. Radiographics.
2007 Mar-Apr;27(2):343-55. PMID:
17374857
Nasir K, Rosen BD, Kramer HJ,
Edvardsen T, Bluemke DA, Liu K,
Lima JA. Regional left ventricular
function in individuals with mild to moderate renal insufficiency: the
Multi-Ethnic Study of Atherosclerosis. Am Heart J.
2007 Apr;153(4):545-51. PMID:
17383292
Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, Gerstenblith G,
Weiss RG, Marban E, Tomaselli GF, Lima JA, Wu KC. Infarct tissue heterogeneity by magnetic resonance
imaging identifies enhanced cardiac arrhythmia susceptibility in patients
with left ventricular dysfunction. Circulation. 2007 Apr
17;115(15):2006-14. Epub 2007 Mar 26
Macedo R, Prakasa K, Tichnell C,
Marcus F, Calkins H, Lima JA, Bluemke
DA. Marked lipomatous infiltration of
the right ventricle: MRI findings in relation to arrhythmogenic right
ventricular dysplasia. AJR Am J Roentgenol. 2007
May;188(5):W423-7.
PMID: 17449737
Dalal D, Jain R, Tandri H, Dong J, Eid SM,
Prakasa K, Tichnell C, James C, Abraham T, Russell SD, Sinha S, Judge DP, Bluemke DA, Marine JE, Calkins
H. Long-term efficacy of catheter ablation of
ventricular tachycardia in patients with arrhythmogenic right ventricular
dysplasia/cardiomyopathy. J Am Coll Cardiol. 2007 Jul
31;50(5):432-40. Epub 2007 Jul 16. PMID: 17662396 [PubMed - indexed for
MEDLINE]
Prakasa KR, Wang J, Tandri H,
Dalal D, Bomma C, Chojnowski R, James C, Tichnell C, Russell S, Judge D,
Corretti M, Bluemke D, Calkins
H, Abraham TP. Utility of tissue Doppler and
strain echocardiography in arrhythmogenic right ventricular
dysplasia/cardiomyopathy. Am J Cardiol. 2007 Aug
1;100(3):507-12. Epub
2007 Jun 15. PMID: 17659937 [PubMed - in process]
Lehman
CD, Isaacs C, Schnall MD, Pisano ED, Ascher SM, Weatherall PT, Bluemke
DA, Bowen DJ, Marcom PK, Armstrong DK,
Domchek SM, Tomlinson G, Skates SJ, Gatsonis C.
Cancer yield of mammography, MR, and US in high-risk women:
prospective multi-institution breast cancer screening study. Radiology.
2007 Aug;244(2):381-8. PMID: 17641362 [PubMed - indexed for MEDLINE]
Vogel-Claussen J, Fishman EK, Bluemke DA. Novel
cardiovascular MRI and CT methods for evaluation of ischemic heart disease.
Expert Rev Cardiovasc Ther. 2007 Jul;5(4):791-802.
PMID: 17605656
Cheung
N, Bluemke DA, Klein R, Sharrett AR, Islam FM, Cotch
MF, Klein BE, Criqui MH, Wong TY. Retinal arteriolar narrowing and left
ventricular remodeling: the multi-ethnic study of atherosclerosis. J
Am Coll Cardiol. 2007 Jul 3;50(1):48-55. Epub 2007 Jun 18. PMID: 17601545
Bomma C, Dalal D, Tandri H,
Prakasa K, Nasir K, Roguin A, Piccini J, Dong J, Mahadevappa M, Tichnell C,
James C, Lima JA, Fishman E, Calkins H, Bluemke DA. Evolving role of multidetector
computed tomography in evaluation of arrhythmogenic right ventricular
dysplasia/cardiomyopathy. Am J Cardiol. 2007 Jul
1;100(1):99-105. Epub 2007 May 21. PMID: 17599449
Wang J, Prakasa K, Bomma C,
Tandri H, Dalal D, James C, Tichnell C, Corretti M, Bluemke D, Calkins H, Abraham TP. Comparison of novel echocardiographic
parameters of right ventricular function with ejection fraction by cardiac
magnetic resonance. J Am Soc Echocardiogr. 2007
Sep;20(9):1058-64. Epub 2007 Jun 6. PMID: 17555927
Hazirolan T, Ozkan E, Erol M, Bluemke DA, Aytemir K, Oto A, Besim
A. Myocardial delayed enhancement imaging: comparison
of two-dimensional and three-dimensional inversion prepared fast gradient
echo and steady state free precession sequences. JBR-BTR. 2007
Mar-Apr;90(2):124-7.PMID: 17555074
Rettmann DW, Saranathan M, Wu
KC, Azevedo CF, Bluemke DA, Foo
TK. High temporal resolution breathheld
3D FIESTA CINE imaging: validation of ventricular function in patients with
chronic myocardial infarction. J Magn Reson Imaging. 2007
Jun;25(6):1141-6. PMID: 17520725
Fayad LM, Barker PB, Jacobs MA,
Eng J, Weber KL, Kulesza P, Bluemke
DA. Characterization of
musculoskeletal lesions on 3-T proton MR spectroscopy. AJR Am J Roentgenol. 2007 Jun;188(6):1513-20.
PMID: 17515370
Steen H, Nasir K, Flynn E, El-Shehaby I, Lai S, Katus HA, Bluemcke D, Lima JA. Is Magnetic Resonance Imaging the 'Reference Standard'
for Cardiac Functional Assessment? Factors Influencing Measurement of Left
Ventricular Mass and Volumes. Clin Res Cardiol. 2007 Sep 7; [Epub
ahead of print] PMID: 17763966
Fernandes VR, Edvardsen T, Rosen
BD, Carvalho B, Campos O, Cordeiro MA, Kronmal R, Bluemke DA, Lima JA. The influence of left ventricular
size and global function on regional myocardial contraction and relaxation
in an adult population free of cardiovascular disease: a tagged CMR study
of the MESA
cohort. J Cardiovasc Magn
Reson. 2007;9(6):921-30.
PMID: 18066753
George
RT, Jerosch-Herold M, Silva C, Kitagawa K, Bluemke DA, Lima JA, Lardo
AC. Quantification of Myocardial
Perfusion Using Dynamic 64-Detector Computed Tomography. Invest Radiol. 2007 Dec;42(12):815-822.
PMID: 18007153
Fernandes VR, Polak JF, Cheng S, Rosen
BD, Carvalho B, Nasir
K, McClelland R, Hundley G, Pearson
G, O'Leary DH, Bluemke DA, Lima
JA. Arterial Stiffness Is Associated
With Regional Ventricular Systolic and Diastolic Dysfunction. The
Multi-Ethnic Study of Atherosclerosis. Arterioscler
Thromb Vasc Biol. 2007
Oct 25; PMID: 17962621
Thurnher S,
Miller S, Schneider G, Ballarati C, Bongartz G, Herborn CU,
Schoenberg S, Cova MA, Morana
G, Niazi K, Iezzi R, Taupitz M, Bluemke
DA, Kreitner KF, Kirchin
MA, Pirovano G.
Diagnostic performance of gadobenate dimeglumine enhanced MR angiography of the iliofemoral and calf arteries: a large-scale
multicenter trial. AJR Am J Roentgenol. 2007 Nov;189(5):1223-37.
PMID: 17954665
Fernandes VR, Wu KC, Rosen BD, Schmidt A, Lardo
AC, Osman N, Halperin HR, Tomaselli G, Berger R, Bluemke DA, Marbán E, Lima JA.
Enhanced
infarct border zone function and altered mechanical activation predict inducibility of monomorphic
ventricular tachycardia in patients with ischemic cardiomyopathy.
Radiology. 2007 Dec;245(3):712-9. Epub 2007 Oct 2. PMID: 17911537
Foo TK, Slavin GS, Bluemke DA, Montequin
M, Hood MN, Ho VB. Simultaneous myocardial and fat
suppression in magnetic resonance myocardial delayed enhancement imaging. J
Magn Reson Imaging.
2007 Oct;26(4):927-33. PMID: 17896381
Tandri H, Macedo R, Calkins H,
Marcus F, Cannom D, Scheinman
M, Daubert J, Estes M 3rd, Wilber D, Talajic M, Duff H, Krahn A,
Sweeney M, Garan H, Bluemke DA;
Multidisciplinary Study of Right Ventricular Dysplasia Investigators. Role of magnetic resonance imaging in
arrhythmogenic right ventricular dysplasia: insights from the North
American arrhythmogenic right ventricular dysplasia (ARVD/C) study. Am
Heart J. 2008 Jan;155(1):147-53. Epub 2007 Sep 14. Erratum in: Am Heart J. 2008 Feb;155(2):289. PMID: 18082506
Liapi E, Geschwind JF, Vossen JA, Buijs M,
Georgiades CS, Bluemke DA, Kamel
IR. Functional MRI evaluation of tumor response in
patients with neuroendocrine hepatic metastasis
treated with transcatheter arterial chemoembolization. AJR Am J Roentgenol.
2008 Jan;190(1):67-73. PMID: 18094295
Xia
J, Seckin E, Xiang Y, Vranesic
M, Mathews WB, Hong K, Bluemke DA,
Lerman LO, Szabo
Z. Positron-emission tomography
imaging of the angiotensin II subtype 1 receptor in swine renal
artery stenosis. Hypertension. 2008 Feb;51(2):466-73.
Epub 2008 Jan 2.
Wasserman
BA, Sharrett AR, Lai S, Gomes AS, Cushman M,
Folsom AR, Bild DE, Kronmal
RA, Sinha S, Bluemke
DA. Risk factor associations
with the presence of a lipid core in carotid plaque of asymptomatic
individuals using high-resolution MRI: the multi-ethnic study of
atherosclerosis (MESA).
Stroke. 2008 Feb;39(2):329-35. Epub
2008 Jan 3. PMID: 18174475
Fayad LM, Barker PB, Bluemke DA. Molecular characterization of
musculoskeletal tumors by proton MR spectroscopy. Semin
Musculoskelet Radiol.
2007 Sep;11(3):240-5.
Gottlieb
I, Pinheiro A, Brinker JA, Corretti
MC, Mayer SA, Bluemke DA, Lima
JA, Marine JE, Berger RD, Calkins H, Abraham TP, Henrikson
CA. Diagnostic accuracy of arterial
phase 64-slice multidetector CT angiography for left atrial appendage
thrombus in patients undergoing atrial fibrillation ablation. J Cardiovasc Electrophysiol.
2008 Mar;19(3):247-51. PMID: 18302696
Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke
DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal
RA. Coronary calcium as a predictor
of coronary events in four racial or ethnic groups. N Engl
J Med. 2008 Mar 27;358(13):1336-45. PMID: 18367736
Soulez G, Pasowicz M, Benea G, Grazioli L, Niedmann JP, Konopka M, Douek PC, Morana G, Schaefer
FK, Vanzulli A, Bluemke DA, Maki JH, Prince MR, Schneider G, Ballarati C, Coulden R, Wasser MN, McCauley TR, Kirchin
MA, Pirovano G.
Renal artery stenosis evaluation: diagnostic performance of gadobenate dimeglumine-enhanced
MR angiography--comparison with DSA. Radiology. 2008 Apr;247(1):273-85.
Epub 2008 Feb 7. PMID: 18372471
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Research Support:
R01 HL78909
(Bluemke)
NHLBI
Coronary
Atherosclerosis Evaluation by Arterial Wall MRI
To
relate coronary wall thickness to subclinical measures of coronary heart
disease.
Foundation
Award (Marban)
Reynolds
Foundation
Evaluation
of Etiologic Factors in Sudden Cardiac Death
To
determine structural correlates in the heart that predict sudden cardiac
death.
5RO1AG021570-03
(Lima)
NIA
HDL
Increased Plaque Stabilization in the Elderly
To
investigate the benefit of increased HDL on atherosclerotic plaque
architecture and composition over and above those achieved by lipid
lowering statin therapy.
5R01DK050183-07
(Szabo)
NIDDKD
Investigation
of Ang II/AT1 Receptors with Pet Role: Co-Investigator
To
assess the role of angiotensin receptor in hypertension with PET.
HL47405
(Prince)
NIH/NHLBI
Harmonic
Phase MRI for Ultrafast Cardiac Strain Imaging
To
implement 3d real time strain methods using MRI.
*5R21CA095907-02
(Ouwerkerk)
NCI
Quantitative
23NaMRI of Breast Cancer Role: Co-Investigator
To
evaluate 23NaMRI for breast cancer.
*5R01AR051874-02
(Stone)
NIAMSD
Vasculitis
Outcome Measures: Development and Validation
To
evaluate MRI for vasculitis evaluation.
*IRAT
Supplement Award
(Abeloff)
NIH/NCI
(Imaging
Response Assessment Teams)
To use
imaging to evaluate tumor response.
*RO1CA100184
(Jacobs)
NIH
NCI
Multiparametric
MRI in Breast Cancer Tissue
To
evaluate the role of novel MRI techniques such as proton MR, sodium,
and spectroscopy in the characterization of breast cancer
N01HC-95168-01(Bluemke)
NIH/NHLBI
Subclinical Cardiovascular Disease Study, MRI Reading
Center
To study the characteristics of subclinical
cardiovascular disease that predict progression to clinically overt cardiovascular
disease
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