Body MRI Faculty

David A. Bluemke, MD, PhD

Professor, Radiology and Medicine 
   

 

 

 


Contact Information

Research Interests

Selected Publications

Research Support

Resources

 

Contact Information:

David A. Bluemke, MD, PhD, MsB, FAHA

Russell H. Morgan Department of Radiology and Radiological Science

Professor of Radiology and Medicine
Department of Radiology

MRI Building Rm 143
600 N. Wolfe Street
Johns Hopkins University School of Medicine
Baltimore MD, 21287-0845
tel: (410) 955-4062, fax: (410) 955-9799
dbluemke@jhmi.edu

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Research Interests:

- Novel cardiovascular MRI and CT methods in the evaluation of myocardial ischemia, heart failure and vascular imaging

- Evaluation of the regional function and pathology of the right heart

- Use of MRI in assessment of markers of subclinical cardiovascular disease.

- Novel methodology in the assessment of oncologic disease

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Selected Publications:

Tandri H, Daya SK, Nasir K, Bomma C, Lima JA, Calkins H, Bluemke DA.   Normal reference values for the adult right ventricle by magnetic resonance imaging. Am J Cardiol. 2006 Dec 15;98(12):1660-4. Epub 2006 Oct 27.  PMID: 17145230 

Gottlieb I, Macedo R, Bluemke DA, Lima JA.   Magnetic resonance imaging in the evaluation of non-ischemic cardiomyopathies: current applications and future perspectives. Heart Fail Rev. 2006 Dec;11(4):313-23.  PMID: 17131077 

Vogel-Claussen J, Pannu H, Spevak PJ, Fishman EK, Bluemke DA.   Cardiac valve assessment with MR imaging and 64-section multi-detector row CT. Radiographics. 2006 Nov-Dec;26(6):1769-84. PMID: 17102049 

Kamel IR, Reyes DK, Liapi E, Bluemke DA, Geschwind JF.   Functional MR imaging assessment of tumor response after 90Y microsphere treatment in patients with unresectable hepatocellular carcinoma. J Vasc Interv Radiol. 2007 Jan;18(1 Pt 1):49-56.  PMID: 17296704

Nasir K, Tsai M, Rosen BD, Fernandes V, Bluemke DA, Folsom AR, Lima JA.   Elevated homocysteine is associated with reduced regional left ventricular function: the Multi-Ethnic Study of Atherosclerosis. Circulation. 2007 Jan 16;115(2):180-7. Epub 2007 Jan 2.  PMID: 17200444

Silber HA, Lima JA, Bluemke DA, Astor BC, Gupta SN, Foo TK, Ouyang P.   Arterial reactivity in lower extremities is progressively reduced as cardiovascular risk factors increase: comparison with upper extremities using magnetic resonance imaging. J Am Coll Cardiol. 2007 Mar 6;49(9):939-45. Epub 2007 Feb 16.  PMID: 17336716

Rosen BD, Cushman M, Nasir K, Bluemke DA, Edvardsen T, Fernandes V, Lai S, Tracy RP, Lima JA.   Relationship between C-reactive protein levels and regional left ventricular function in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol. 2007 Feb 6;49(5):594-600. Epub 2007 Jan 22.  PMID: 17276184

Lehman CD, Gatsonis C, Kuhl CK, Hendrick RE, Pisano ED, Hanna L, Peacock S, Smazal SF, Maki DD, Julian TB, DePeri ER, Bluemke DA, Schnall MD; ACRIN Trial 6667 Investigators Group.  MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med. 2007 Mar 29;356(13):1295-303

Kawamoto S, Permpongkosol S, Bluemke DA, Fishman EK, Solomon SB.   Sequential changes after radiofrequency ablation and cryoablation of renal neoplasms: role of CT and MR imaging. Radiographics. 2007 Mar-Apr;27(2):343-55.  PMID: 17374857

Nasir K, Rosen BD, Kramer HJ, Edvardsen T, Bluemke DA, Liu K, Lima JA.   Regional left ventricular function in individuals with mild to moderate renal insufficiency: the Multi-Ethnic Study of Atherosclerosis. Am Heart J. 2007 Apr;153(4):545-51.  PMID: 17383292

Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, Gerstenblith G, Weiss RG, Marban E, Tomaselli GF, Lima JA, Wu KC.   Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation. 2007 Apr 17;115(15):2006-14. Epub 2007 Mar 26

Macedo R, Prakasa K, Tichnell C, Marcus F, Calkins H, Lima JA, Bluemke DA.   Marked lipomatous infiltration of the right ventricle: MRI findings in relation to arrhythmogenic right ventricular dysplasia. AJR Am J Roentgenol. 2007 May;188(5):W423-7.  PMID: 17449737

Dalal D, Jain R, Tandri H, Dong J, Eid SM, Prakasa K, Tichnell C, James C, Abraham T, Russell SD, Sinha S, Judge DP, Bluemke DA, Marine JE, Calkins H.  Long-term efficacy of catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol. 2007 Jul 31;50(5):432-40. Epub 2007 Jul 16. PMID: 17662396 [PubMed - indexed for MEDLINE]

Prakasa KR, Wang J, Tandri H, Dalal D, Bomma C, Chojnowski R, James C, Tichnell C, Russell S, Judge D, Corretti M, Bluemke D, Calkins H, Abraham TP.  Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2007 Aug 1;100(3):507-12. Epub 2007 Jun 15. PMID: 17659937 [PubMed - in process]

Lehman CD, Isaacs C, Schnall MD, Pisano ED, Ascher SM, Weatherall PT, Bluemke  DA, Bowen DJ, Marcom PK, Armstrong DK, Domchek SM, Tomlinson G, Skates SJ, Gatsonis C.  Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study. Radiology. 2007 Aug;244(2):381-8. PMID: 17641362 [PubMed - indexed for MEDLINE]

Vogel-Claussen J, Fishman EK, Bluemke DA.  Novel cardiovascular MRI and CT methods for evaluation of ischemic heart disease. Expert Rev Cardiovasc Ther. 2007 Jul;5(4):791-802. PMID: 17605656

Cheung N, Bluemke DA, Klein R, Sharrett AR, Islam FM, Cotch MF, Klein BE, Criqui MH, Wong TY.  Retinal arteriolar narrowing and left ventricular remodeling: the multi-ethnic study of atherosclerosis. J Am Coll Cardiol. 2007 Jul 3;50(1):48-55. Epub 2007 Jun 18. PMID: 17601545

Bomma C, Dalal D, Tandri H, Prakasa K, Nasir K, Roguin A, Piccini J, Dong J, Mahadevappa M, Tichnell C, James C, Lima JA, Fishman E, Calkins H, Bluemke DA.  Evolving role of multidetector computed tomography in evaluation of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2007 Jul 1;100(1):99-105. Epub 2007 May 21. PMID: 17599449

Wang J, Prakasa K, Bomma C, Tandri H, Dalal D, James C, Tichnell C, Corretti M, Bluemke D, Calkins H, Abraham TP.  Comparison of novel echocardiographic parameters of right ventricular function with ejection fraction by cardiac magnetic resonance. J Am Soc Echocardiogr. 2007 Sep;20(9):1058-64. Epub 2007 Jun 6. PMID: 17555927

Hazirolan T, Ozkan E, Erol M, Bluemke DA, Aytemir K, Oto A, Besim A.  Myocardial delayed enhancement imaging: comparison of two-dimensional and three-dimensional inversion prepared fast gradient echo and steady state free precession sequences. JBR-BTR. 2007 Mar-Apr;90(2):124-7.PMID: 17555074

Rettmann DW, Saranathan M, Wu KC, Azevedo CF, Bluemke DA, Foo TK.  High temporal resolution breathheld 3D FIESTA CINE imaging: validation of ventricular function in patients with chronic myocardial infarction. J Magn Reson Imaging. 2007 Jun;25(6):1141-6. PMID: 17520725

Fayad LM, Barker PB, Jacobs MA, Eng J, Weber KL, Kulesza P, Bluemke DA.  Characterization of musculoskeletal lesions on 3-T proton MR spectroscopy. AJR Am J Roentgenol. 2007 Jun;188(6):1513-20. PMID: 17515370

  Steen H, Nasir K, Flynn E, El-Shehaby I, Lai S, Katus HA, Bluemcke D, Lima JA.  Is Magnetic Resonance Imaging the 'Reference Standard' for Cardiac Functional Assessment? Factors Influencing Measurement of Left Ventricular Mass and Volumes. Clin Res Cardiol. 2007 Sep 7; [Epub ahead of print] PMID: 17763966

Fernandes VR, Edvardsen T, Rosen BD, Carvalho B, Campos O, Cordeiro MA, Kronmal R, Bluemke DA, Lima JA.  The influence of left ventricular size and global function on regional myocardial contraction and relaxation in an adult population free of cardiovascular disease: a tagged CMR study of the MESA cohort. J Cardiovasc Magn Reson. 2007;9(6):921-30. PMID: 18066753

George RT, Jerosch-Herold M, Silva C, Kitagawa K, Bluemke DA, Lima JA, Lardo AC.  Quantification of Myocardial Perfusion Using Dynamic 64-Detector Computed Tomography. Invest Radiol. 2007 Dec;42(12):815-822. PMID: 18007153

Fernandes VR, Polak JF, Cheng S, Rosen BD, Carvalho B, Nasir K, McClelland R,  Hundley G, Pearson G, O'Leary DH, Bluemke DA, Lima JA.  Arterial Stiffness Is Associated With Regional Ventricular Systolic and Diastolic Dysfunction. The Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2007 Oct 25; PMID: 17962621

 Thurnher S, Miller S, Schneider G, Ballarati C, Bongartz G, Herborn CU, Schoenberg S, Cova MA, Morana G, Niazi K, Iezzi R, Taupitz M, Bluemke DA, Kreitner KF, Kirchin MA, Pirovano G.  Diagnostic performance of gadobenate dimeglumine enhanced MR angiography of the iliofemoral and calf arteries: a large-scale multicenter trial. AJR Am J Roentgenol. 2007 Nov;189(5):1223-37.  PMID: 17954665

Fernandes VR, Wu KC, Rosen BD, Schmidt A, Lardo AC, Osman N, Halperin HR, Tomaselli G, Berger R, Bluemke DA, Marbán E, Lima JA.  Enhanced infarct border zone function and altered mechanical activation predict inducibility of monomorphic ventricular tachycardia in patients with ischemic cardiomyopathy. Radiology. 2007 Dec;245(3):712-9. Epub 2007 Oct 2. PMID: 17911537

Foo TK, Slavin GS, Bluemke DA, Montequin M, Hood MN, Ho VB.  Simultaneous myocardial and fat suppression in magnetic resonance myocardial delayed enhancement imaging. J Magn Reson Imaging. 2007 Oct;26(4):927-33. PMID: 17896381

Tandri H, Macedo R, Calkins H, Marcus F, Cannom D, Scheinman M, Daubert J, Estes M 3rd, Wilber D, Talajic M, Duff H, Krahn A, Sweeney M, Garan H, Bluemke DA; Multidisciplinary Study of Right Ventricular Dysplasia Investigators.  Role of magnetic resonance imaging in arrhythmogenic right ventricular dysplasia: insights from the North American arrhythmogenic right ventricular dysplasia (ARVD/C) study. Am Heart J. 2008 Jan;155(1):147-53. Epub 2007 Sep 14. Erratum in: Am Heart J. 2008 Feb;155(2):289. PMID: 18082506

Liapi E, Geschwind JF, Vossen JA, Buijs M, Georgiades CS, Bluemke DA, Kamel IR.  Functional MRI evaluation of tumor response in patients with neuroendocrine hepatic metastasis treated with transcatheter arterial chemoembolization. AJR Am J Roentgenol. 2008 Jan;190(1):67-73. PMID: 18094295

Xia J, Seckin E, Xiang Y, Vranesic M, Mathews WB, Hong K, Bluemke DA, Lerman LO, Szabo Z.  Positron-emission tomography imaging of the angiotensin II subtype 1 receptor in  swine renal artery stenosis. Hypertension. 2008 Feb;51(2):466-73. Epub 2008 Jan 2.

Wasserman BA, Sharrett AR, Lai S, Gomes AS, Cushman M, Folsom AR, Bild DE, Kronmal RA, Sinha S, Bluemke DA.  Risk factor associations with the presence of a lipid core in carotid plaque of asymptomatic individuals using high-resolution MRI: the multi-ethnic study of atherosclerosis (MESA). Stroke. 2008 Feb;39(2):329-35. Epub 2008 Jan 3. PMID: 18174475

Fayad LM, Barker PB, Bluemke DA.  Molecular characterization of musculoskeletal tumors by proton MR spectroscopy. Semin Musculoskelet Radiol. 2007 Sep;11(3):240-5.

Gottlieb I, Pinheiro A, Brinker JA, Corretti MC, Mayer SA, Bluemke DA, Lima JA, Marine JE, Berger RD, Calkins H, Abraham TP, Henrikson CA.  Diagnostic accuracy of arterial phase 64-slice multidetector CT angiography for left atrial appendage thrombus in patients undergoing atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2008 Mar;19(3):247-51. PMID: 18302696

Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA.  Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008 Mar 27;358(13):1336-45. PMID: 18367736

Soulez G, Pasowicz M, Benea G, Grazioli L, Niedmann JP, Konopka M, Douek PC, Morana G, Schaefer FK, Vanzulli A, Bluemke DA, Maki JH, Prince MR, Schneider G, Ballarati C, Coulden R, Wasser MN, McCauley TR, Kirchin MA, Pirovano G.  Renal artery stenosis evaluation: diagnostic performance of gadobenate dimeglumine-enhanced MR angiography--comparison with DSA. Radiology. 2008 Apr;247(1):273-85. Epub 2008 Feb 7. PMID: 18372471

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Research Support:

 

R01 HL78909   (Bluemke)                                                                                    

NHLBI                                                                                                

Coronary Atherosclerosis Evaluation by Arterial Wall MRI

To relate coronary wall thickness to subclinical measures of coronary heart disease.

 

Foundation Award (Marban)                                                                        

Reynolds Foundation                                                   

Evaluation of Etiologic Factors in Sudden Cardiac Death

To determine structural correlates in the heart that predict sudden cardiac death.

 

5RO1AG021570-03 (Lima)                                                                                                  

NIA                                                    

HDL Increased Plaque Stabilization in the Elderly

To investigate the benefit of increased HDL on atherosclerotic plaque architecture and composition over and above those achieved by lipid lowering statin therapy.

 

5R01DK050183-07  (Szabo)                                     

NIDDKD                                                                                             

Investigation of Ang II/AT1 Receptors with Pet Role:  Co-Investigator

To assess the role of angiotensin receptor in hypertension with PET.

 

HL47405 (Prince)                                                    

NIH/NHLBI                                          

Harmonic Phase MRI for Ultrafast Cardiac Strain Imaging

To implement 3d real time strain methods using MRI.

 

*5R21CA095907-02 (Ouwerkerk)                                                                  

NCI                                                                                                    

Quantitative 23NaMRI of Breast Cancer Role:  Co-Investigator

To evaluate 23NaMRI for breast cancer.

 

*5R01AR051874-02 (Stone)                                                                          

NIAMSD                                                                                             

Vasculitis Outcome Measures:  Development and Validation

To evaluate MRI for vasculitis evaluation.

 

*IRAT Supplement Award (Abeloff)                                                                          

NIH/NCI                                                                                             

(Imaging Response Assessment Teams)

To use imaging to evaluate tumor response.

                     

*RO1CA100184 (Jacobs)                                                                                      

NIH NCI                                                                                                         

Multiparametric MRI in Breast Cancer Tissue

To evaluate the role of novel MRI techniques such as proton MR, sodium, and  spectroscopy in the characterization of breast cancer

 

N01HC-95168-01(Bluemke)                                      

NIH/NHLBI                                          

Subclinical Cardiovascular Disease Study, MRI Reading Center

To study the characteristics of subclinical cardiovascular disease that  predict progression to clinically overt cardiovascular disease

 

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